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Clinical evidence on the involvement of gut-related factors in osteoporosis led us to undertake the core concept of the gutbone axis and systematically summarize that the intestinal intrinsic structure, gut microbiota, and derived metabolites, with the immune and endocrine routes as the intermediate transitions, attain a bidirectional interplay with skeletal tissue through the gutbone axis
37 , BSR20170898 (2017)
this strategy provides a clear blueprint for combining GSH-sensing motifs with organelle-specific drug release to increase tumor selectivity and potency [20]
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
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