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Gastrointestinal side effects are more common due to its potency

Berberine is an insulin secretagogue targeting the KCNH6 potassium channel

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Combination therapies, like Novo Nordisk's CagriSema (GLP-1 and amylin analogues), are also advancing, potentially offering similar weight loss benefits while preserving more lean mass, addressing concerns about muscle loss

[20] Symptoms like irritability, anxiety, poor sleep, gross motor problems or problems with coordination, tics, seizures, vision problems, developmental delay and/or slowing of typical development, and depression have been reported in those with FRAs and while testing folate levels in the CSF is too invasive, a test for folate receptor antibodies is available

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