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Therefore, we found that the enhanced insulinotropic effect of exendin-phe1 in vitro is recapitulated in a mouse model of T2D, suggesting that GLP-1R trafficking plays a role in determining the responses to therapeutic GLP-1R agonists in vivo

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10.1093/eurheartj/ehad842 41 MaX.MengJ.JiaM.BiL.ZhouY.WangY.et al (2013)

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