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Cleveland Clinic notes that large calorie deficits can contribute to fatigue. When recovery is impaired, training performance and adaptation may be affected

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GPX4-null mice undergo embryonic lethality, whereas conditional GPX4-mutant mice result in ferroptosis, neurodegeneration [112], loss of antiviral immunity [113], infertility, and ischemia-reperfusion injury in the kidney and liver [114]

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Only recently fatigue has been included among the most important symptoms in cancer patients, and its evaluation is still not routinely included among the symptoms attributable to the toxicity of chemotherapy [67]

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Anecdotal Community Protocols The Dihexa research community has coalesced around a range of dosing practices based on anecdotal self-experimentation and discussion

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The following subsections unpack how delayed gastric emptying produces nausea and other contributing factors clinicians consider when counseling patients

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