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Recently, it was reported that Propionibacterium acnes induces substance P and CGRP expression in the IVD and obvious LBP symptoms by stimulating NP cells to secrete the pro-algesic factor IL-8/CINC-1 through the TLR2-NF-B p65 pathway, which may provide a promising alternative therapeutic strategy for LBP patients in the clinic

A., Darko, E

The treatment most patients underestimate

Their primary rationale is to smooth plasma concentrationtime profiles, exploit passive accumulation and reduce specific toxicities such as cardiotoxicity, hypersensitivity to solvents or certain hematological events [106, 108]

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