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doi: 10.3389/fimmu.2021.714177 7 KimWEganJM

Flutamide versus prednisone in patients with prostate cancer symptomatically progressing after androgen-ablative therapy: a phase III study of the European organization for research and treatment of cancer genitourinary group

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This commonly triggers a more Th1/Th17-driven immune response, driven by release of interleukin-1 alpha (IL-1), interleukin-1 beta (IL-1), tumor necrosis factor- (TNF-), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-8 (IL-8) from keratinocytes following irritant exposure