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Vitamin C helps regenerate glutathione after it has been used up, keeping it active longer inside the body

Tumor-microenvironment-activated reactive oxygen species amplifier for enzymatic cascade cancer starvation/chemodynamic/immunotherapy

The targets of current GSH depleting agents are mainly located in the cytosol or cell membrane, as the cytosol is the central hub for GSH biosynthesis (Figure 2)

Sulforaphane is widely recognized in clinical literature as the most potent naturally occurring activator of the Nrf2 (Nuclear factor erythroid 2-related factor 2) signaling pathway

These findings suggest that the presence of the distinct microbiota can counteract the immunosuppressive TME in sensitive mice [192]

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