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A study in adults aged 70 and older showed increased heteroplasmy linked to an increased depression score.[ref] Rare mitochondrial mutations that cause mitochondrial diseases are also linked to major depressive disorder.[ref] In fact, one study of people with hereditary (genetic) mitochondrial diseases showed that 54% had major depressive disorder and 17% had bipolar disorder.[ref] Outside of the mitochondrial genome, genes in the nuclear genome that code for proteins in the mitochondria are also linked to depression
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In addition, the European Commission approved the product in 2018 as a novel food ingredient named MGCPQQ , after passing the European Food Safety assessment ( Obesity and its related co-morbidities are increasing globally
Berberine also restored protein phosphate 2A (PP2A) activity and glycogen synthase kinase 3 (GSK-3) activity (GSK-3 Tyr216 and Ser9 site phosphorylation increased) (Yu et al., 2011)
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