The GPx family and its members GPxs are members of a multiple-isozyme family that catalyze the reduction of H 2 O 2 or organic hydroperoxides to generate water or corresponding alcohols using reduced glutathione (GSH) as an electron donor [11]
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As such, its actions as a signaling molecule may be even more critical than those of a ROS scavenger (Diotallevi et al., 2017)
Consequently, a change in GSH or GSSG can arise from altered substrate availability or enzyme activity even when ROS production is unchanged
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Another important factor was it had the capacity to bind to albumin, a large protein common in the bloodstream, which would make the GLP-1 molecule too large to be quickly cleared by the kidney
