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The FDA label indicates that discontinuation may be considered if less than 5% weight loss is achieved after approximately 12 weeks on the maintenance dose

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Implementation of the low FODMAP diet in functional gastrointestinal symptoms: A real-world experience

10.1371/journal.pone.0037512 32 SauzayC.LouandreC.BodeauS.AngladeF.GodinC.SaidakZ.et al (2018)

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Although the different pre-pro-IGF-1s eventually give rise to the same mature 70-amino acid IGF-1 molecule, it has been shown that these variants have different stabilities, binding partners, and activity