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However, the treatment landscape has seen significant changes in the past five years, with several late-phase candidates in development

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In the Phase 2 obesity trial published in NEJM in 2023, retatrutide at the 12 mg weekly dose produced a mean placebo-adjusted body weight reduction of 22.1 percentage points (22.1% (24.2% arm) mean absolute reduction on the retatrutide arm) at 48 weeks (Jastreboff et al., NEJM, 2023)

In the brain, mast cell-derived mediators interact with microglia , the central nervous systems resident immune cells