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TRIM21 interacts with a site at the CH2CH3 domain interface of the Fc region of IgG bound to virus, which results in ubiquitylation of the antibody-bound virus complex and recruitment to the proteasome for degradation

10 Conclusions and future directions While the existence of physical stimuli within the breast tumor microenvironment and throughout the metastatic cascade has been acknowledged for several decades, our understanding of their role in breast cancer remains incomplete