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In addition, they cause the upregulation of genes coding for proinflammatory cytokines, thus contributing to the initiation of a vicious cycle that is self-feeding (47)

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Additionally, the expression of oxidatively modified proteins and lipid peroxidation-derived products, such as 13-hydroperoxy-9Z,11E-octadecadienoic acid and 4-hydroxy-2-nonenal, was significantly increased in the brains of the T21 mouse models

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