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In breast cancer cell lines, it was shown that Cycloguanil and its most promising analogue, NSC127159, were shown to inhibit Dihydrofolate reductase (DHFR), an established anti-cancer drug target whose inhibition disrupts folate metabolism and STAT3-dependent gene expression

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| Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2

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(2007) N-acetyl-L-cysteine improves outcome of advanced cerebral adrenoleukodystrophy