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Although exogenous GIP does not lower glucose in diabetic patients, making it unsuitable for DM2 treatment alone, new GLP-1-GIP co-agonists show promising antidiabetic and weight-reducing effects

10.3390/ijms22094312 59 LiW.ZhangH.ChenJ.TanY.LiA.GuoL

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It is also not recommended for use in patients suffering from severe Leber hereditary optic neuropathy (inherited form of vision loss), and/or runny nose/nasal blockage

But what I do want to say is the resort is hard to make, and it's because of this one purpose