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The rupture of the physical barrier (OMM) that limits their release into the cytosol constitutes a point-of-no-return in cell death (Martinou and Green, 2001

Areas of hemorrhage and necrosis may be present

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Orthobiologics and Injection therapies Platelet Rich Plasma (PRP) PRP therapy injects a high concentration of platelets extracted from the patients own blood into the knee joint, triggering the release of biologically active agents such as growth factors, cytokines, lysosomes and adhesion proteins to initiate and accelerate tissue healing

However, it is important to note that these findings are largely limited to animal studies, and clinical evidence remains scarce