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It is important to appreciate, however, that the increased risk relates to a disorder that is relatively uncommon. Given the numbers of participants who have been recruited to clinical trials and the large number of people globally who use GLP-1 RAs, we should be confident that if corroborated, the absolute risk of developing NAION in direct relation to taking semaglutide must indeed be rare, Susan Mollan, MBcHP, of University Hospitals Birmingham NHS Foundation Trust , in England, wrote in a commentary published with the study

While microdosing GLP-1s may be beneficial for a variety of reasons for certain individuals, the growing interest in microdosing GLP-1s can at least in part be tied to the significant metabolic shifts women experience during perimenopause and menopause

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FDA approved in November 2023 The FDA recently approved a new Eli Lilly drug, Zepbound (tirzepatide), for chronic weight management in adults with at least one weight-related health condition

Orlistat blocks lipases, preventing some dietary fat from being digested

This can lead to better overall management of diabetes and improved health outcomes