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Through multifaceted mechanisms, miRNAs integrate oncogenic signaling with extrinsic stress responses, positioning them as key modulators of metabolic adaptation.miRNAs exert fine-tuned control over a wide array of metabolic pathways, including glycolysis, OXPHOS, fatty acid and amino acid metabolism, mitochondrial dynamics, and redox homeostasis [9]

Critical neurotransmitters in the neuroimmune network

Moreover, administration of ATRA mitigated diabetic nephropathy in a TLR4-dependent manner (Sierra-Mondragon et al

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For example, the neurotoxin models of PD (using MPTP or 6-OHDA) recapitulate features of the diseaseelevated -synuclein, astrocyte activation, bloodbrain barrier disruption, inflammation, oxidative stress, and dopaminergic neuron lossand these models have demonstrated the neuroprotective potential of various dietary polyphenols (10)

PMID: 27 VincetiMFilippiniTDel GiovaneCDennertGZwahlenMBrinkmanMet al