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Some practitioners adjust doses for individuals at extreme ends of the weight spectrum (under 120 lbs or over 300 lbs), but standard protocols use fixed dosing

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cyano-B12 decreased the frequency of recurrent aphthous ulcers in patients with normal (defined as a B12 status of 140 ng/l) as well as with low levels of B12 at baseline

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Lifelong supplementation with a complete multivitamin and mineral supplement, as recommended by BOMSS, is widely advised in addition to targeted B12 supplementation where indicated