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Author contributions Both authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication

Olivieri et al

Some patients have had alternating episodes of typical "high-uptake" thyrotoxicosis and episodes of "transient" low-uptake thyrotoxicosis(69)

The RIA method exploits the binding reaction between an antibody, a type of protein produced by the immune system, and an antigen, a type of protein found on the surface of foreign substances

median survival times are approximately 10 to 15 years in asymptomatic patients and 7 years in symptomatic patients

10.1016/S1474-4422(19)30034-1 41