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All of these studies are hypothesis-generating and await confirmation in RCTs. According to Lane, the rationale for GLP-1 receptor agonists in lupus stems from the drugs demonstrating anti-inflammatory properties, potentially by inhibiting the NF-B pathway, which plays a crucial role in inflammation

J Pediatr 1992

10.1186/s12876-023-02689-4 259 ZimmermannS

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Exploring the multifaceted functions of astrocytes in the brain Astrocytes are a jack-of-all trades in the brain Astrocytes have many functional, physiological and metabolic roles in regulating the nervous system across different regions, including the brain, spinal cord and retina 11

In the case of the JNK inhibitor SP600125, which is only soluble in DMSO and requires early treatment, 70% of the protection against APAP toxicity was caused by DMSO and 30% by SP600125 [36]