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This phenomenon results in an injury to the skin or the underlying tissue or organ termed a wound

3 Studies indicate women with PCOS are more than three times as likely to experience depressive symptoms and over six times more likely to experience anxiety symptoms than those without PCOS

The imidazole nitrogen of the histidine side chain donates one of the three nitrogen ligands to the copper, and the position of histidine at the second residue is what enables the deprotonated amide nitrogen of the preceding Gly-His peptide bond to also coordinate the copper

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