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A 2023 study published in Nature Metabolism found that GLP-1 receptor agonists may reduce alcohol cravings and intake in individuals with obesity or alcohol use disorders

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34 Lanifibranor (IVA337) is a pan-PPAR agonist of PPAR-, PPAR-/, and PPAR-

In Phase 2 trial data, the most commonly reported adverse effects included: Nausea (reported in a significant proportion of participants, particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite (which, whilst contributing to weight loss, can occasionally be excessive) These effects were generally described as mild to moderate in severity and tended to diminish over time as the body adjusted to the medication