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Cycles run 8-12 weeks on, 4 weeks off

2022;94 doi: 10.1016/j.phymed.2021.153841

The peptide's activation of ERK1/2 and downstream transcription factors including Egr-1 drives expression of collagen synthesis genes while its enhancement of cellular migration ensures efficient fibroblast recruitment to sites requiring matrix deposition, creating optimal conditions for rapid yet organized tissue reconstruction

The peptides for osteoporosis guide covers this specifically, while the peptides for bone healing and peptides for bone and cartilage repair articles address the underlying mechanisms