An approach targeting both risk factors if they coexist is the basis for primary and secondary prevention of cardiovascular events
Still unlicensed in humans outside of research investor.lilly.com/news-releases/ TRIUMPH-1: #retatrutide topline data Phase 3, n=2,339, 80 wk, obesity without diabetes (efficacy estimand): 12 mg: -28.3% body weight (-31.9 kg) 9 mg: -25.9% | 4 mg: -19.0% | Placebo: -2.2% 30% weight loss: 45.3% vs 0.5% 104-wk extension (BMI 35, n=532), 12 mg MTD: -30.3% Cross-trial context (obesity, no diabetes): STEP-1 SEMA 2.4 mg, 68 wk: -14.9% SURMOUNT-1 TZP 15 mg, 72 wk: -20.9% TRIUMPH-1 RETA 12 mg, 80 wk: -28.3% But: Topline press release
It is a concentrated blend of hydration and immune-optimizing nutrients
It helps regulate several hormones (e.g., improving insulin sensitivity) and increases the number of androgen receptors in muscle cells, as shown in an in vivo study where it was consumed for 21 days
Overall, the biochemical mechanisms of COVID-19-induced tissue damage are complex and involve a range of metabolism-disturbing processes, including inflammation, hypoxia, energy deficiency, and accumulation of metabolic intermediates [45]
Figures 3d and h)
