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Specifically, EGF has been implicated in stimulating spermatogenesis and reducing germ cell apoptosis [101], while TGF-1 downregulates pro-inflammatory cytokines such as IL-1 [102]

Radwan M, Jurewicz J, Polaska K, Sobala W, Radwan P, Bochenek M, et al

Studies Investigating IGF-1 and Related Analogs in Cellular and Metabolic Research Models

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First-generation GHRPs such as GHRP-6 were identified through systematic screening of met-enkephalin analogs and demonstrated potent GH release but with significant off-target effects including appetite stimulation, cortisol elevation, and aldosterone release

The scientists suggested that there may have been a correlated increase in the animals body weight and BMC, as measured by dual X-ray absorptiometry (DXA)