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Unlike NSAIDs, which block pain signals without addressing tissue damage, peptides involved in joint repair target four biological mechanisms

[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Khan AA, Allemailem KS, Almatroodi SA, Almatroudi A, Rahmani AH

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10.3390/antiox10111644 5 AliS.CorbiG.MaesM.ScapagniniG.DavinelliS

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Moreover, glutathione plays an important role in NO metabolism: glutathione reacts with peroxynitrite from S-nitrosothiols (RSNOs), which subsequently release NO over a prolonged time to extend the half-life of NO, thereby preventing the negative effects of NO scavenging by superoxide