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http : .org/10.1007/s 10803-008-0591-5 72

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Interestingly, higher incidence of diabetic retinopathy (DR) complications was noted in patients taking semaglutide (3.0%) compared to placebo (1.5%) in clinical trials, with greater risk in those with a history of DR [32]

According to a 2016 study published in Currents in Neuropharmacology, it may also support the gut-brain barrier, which offers neuroprotective effects ( 7 )

32 Since the partial 5UTR of p70S6K1 mRNA forms a secondary structure with the free energy of 82.30 kcal/mol, it is most likely that Pdcd4 inhibits the p70S6K1 translation via repressing eIF4A activity