For mild itching or discomfort , over-the-counter non-drowsy antihistamines (such as cetirizine or loratadine) may provide relief, particularly if symptoms suggest an allergic component
Seek immediate medical attention (call 999 or attend A&E) if you develop : Signs of severe dehydration: dizziness, confusion, reduced urine output despite drinking fluids, rapid heartbeat Symptoms of diabetic ketoacidosis: excessive thirst, frequent urination, nausea, vomiting, abdominal pain, fruity-smelling breath, confusion (Note: GLP-1 medications do not cause DKA, but it can occur in type 1 diabetes or ketosis-prone type 2 diabetes, especially during illness) Severe flank pain with fever: may indicate pyelonephritis (kidney infection) If you experience persistent vomiting or diarrhoea from GLP-1 therapy and cannot maintain adequate fluid intake, seek urgent medical advice as there is a risk of dehydration and acute kidney injury
You build up to it over 16 to 20 weeks
The week-by-week timeline for retatrutide appears compressed, with researchers reporting faster onset of appetite suppression and earlier weight loss milestones
(October 2025)
Dose adjustments may be necessary based on various clinical scenarios and patient-specific factors