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The subcutaneous administration of any medication can cause temporary irritation of nerve endings in the skin and subcutaneous tissue
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Time since semaglutide injection did not affect effort-based decision-making Within the type-2 diabetes, on semaglutide group, time since injection did not affect decision-making (within-subjects comparison of one to six days since injection, n = 25: t (24) = 0.237, p = 0.814), or questionnaire-based measures (SHAPS: t (24) = 0.03, p = 0.98
Pinch the skin: For subcutaneous injections, gently pinching a fold of skin can help ensure proper depth and reduce discomfort. Andrew Cox, PharmD, MBA Learn how to give a subcutaneous injection