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These include blood concentrations of total cobalamin, holo-transcobalamin (vitamin B 12 bound to transcobalamin, one of the two carrier proteins in blood

Typical research doses of 250-500 mcg translate to 10-20 units, right in the practical sweet spot

Methods Mol Biol (2012) 864:125

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What they found: Preventive administration: 70 to 85 % reduction in ulcer area Therapeutic administration: 60 to 75 % reduction And now the most interesting part: 10 ng/kg worked just as well as 10 g/kg Why it matters: If the molecule worked in a stoichiometric way (= simply blocking something piece by piece), a higher dose would necessarily produce a larger effect

Biotin is water-soluble