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Patients and providers should treat them as directional rather than definitive, and decisions about participating in trials or accessing investigational therapies should always involve a specialist in endocrinology or metabolic medicine
Endotext [Internet]
Early on, the tissue is being actively re-signaled and needs the most consistent exposure, so activation is daily
In such cases, Vitamin B12 injections can be a lifesaver
Ideally, once platelet-based microvehicles bind to atherosclerotic sites, they would sharply switch to ultrasmall nanoparticles for deep plaque penetration and lesional macrophage intervention
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