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751 participants across 32 sites in the United States and Puerto Rico 72-week treatment duration 1:1 randomization to Tirzepatide or Semaglutide Maximum tolerated dose used for both medications Primary endpoint: percent change in body weight at week 72 Participants received either the maximum tolerated dose of Tirzepatide (10mg or 15mg) or the maximum tolerated dose of Semaglutide (1.7mg or 2.4mg)

the relevance of these findings to humans is currently unknown, and no causal link has been established in human trials to date

Current pricing levels (~USD 900/month) keep adoption in single digits, but every halving of net price can nearly double penetration, provided supply and prescriber infrastructure are stable

Kelvas says

That compared with a 0.8 percentage point fall in the placebo group

References Pope C