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A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas

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Each gene expression experiment was performed at least 3 times and calculations were made from measurements of 3 replicates of each sample

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This finding has direct implications for research protocol design: most published and structured study designs incorporate a rest period following the active phase to allow receptor sensitivity to normalize before any subsequent research cycle, rather than using continuous, uninterrupted administration

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We observed that pravastatin induced higher H 2 O 2 production rate (40%), decreased activity of aconitase (28%), a superoxide-sensitive Krebs cycle enzyme, and increased susceptibility to Ca 2+ -induced MPT (32%) in liver mitochondria

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