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Jan 1 2018;24(1):86-105

At present, diagnostic tools for neurodegenerative diseases primarily rely on the assessment of late-stage clinical symptoms or costly neuroimaging examinations and lack pathology-based biomarkers that would enable intervention in the early stages of the disease (76)

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and other: loss of appetite, altered smell, body weight variations, myalgia, altered smell, otalgia, ophthalmologic (conjunctivitis, dry eyes), fever, changes in menstruation, urinary symptoms, dysphagia, speech disturbances (157159)

K., Alfert M., Castrillon D