Chub-S7 cells cultured in low B12 showed significantly increased pro-inflammatory cytokine gene expression such as IL- 1, IL- 6, IL- 8, IL- 18, MCP- 1, TGF-, and TNF- compared to control (Fig
B12s Role in Nerve Health : Vitamin B12 supports nerve function and helps prevent nerve damage, which is critical for individuals dealing with the effects of diabetes
Abstract Background Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection
Adomako, A
What they found (summary): Amylin is a critical partner of insulin in metabolism, the loss of amylin in T2DM is as significant as the loss of insulin The AMY1 receptor in the area postrema is the primary target for the appetite effect Amyloid aggregation is the main problem with native amylin, proline substitutions (the Pramlintide strategy) are essential The half-life of native amylin is only 13 minutes, that is why lipidated analogs like Cagrilintide are necessary Perspective: amylin + GLP-1 combinations are the natural evolution of metabolic pharmacotherapy Why it matters: This is the reference article for amylin pharmacology
T., Therriault, H., Cantin, A