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Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds

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The theory is that lower doses may provide the inflammatory marker reductions documented in research while minimizing GI side effects and metabolic disruption

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Seo JS, Lee SY, Won KJ, Kim DJ, Sohn DS, Yang KM, Cho SH, Park JD, Lee KH, Kim HD