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Genetic predisposition to SLE includes the expression of TLR variants that promote hyperresponsiveness towards luminal microbes and their products

For example, a recent clinical trial found that people with stable bipolar disorder who took liraglutide lost weight, lowered A1C (a key diabetes marker), and reduced binge eating

Layden AJ, Tse K, Finkelstein JL

doi: 10.1016/j.ejphar.2015.09.024 186 SonH.BanasrM.ChoiM.ChaeS

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The episode covers several treatment approaches that target these dysfunctional brain circuits, including transcranial magnetic stimulation (TMS), ketamine, psilocybin, MDMA, ibogaine, and ayahuasca