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Convenience is the absolute primary driver and systemic effects are a secondary, or even non-existent, concern

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Best Practice & Research Clinical Endocrinology & Metabolism, 31 (1), 91-111

The pharmacological interaction between nitrofurantoin and alcohol is genuinely low risk based on the NHS and the academic evidence

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To have the most realistic biological average for the initial values of all variables (concentrations, membrane potential, mitochondria membrane potential, venous volume, and gating variables) according to the literature, we considered not only measured and modeled literature data on the absolute values themselves but also additional constraints, such as known ratios of NADH to NAD + in the neuron (7779) and astrocyte (79)