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We visualized single-cell data via principal component analysis (PCA) considering only the expression of proteins associated with cellular metabolism (GLUT1, HK, GAPDH, LDHA, G6PD, CD98, CS, ATP5A, CD36, CPT1A, ACADM, ACLY, FASN, SCD1, LAL, mTOR, pAKT, pS6, AMPK), and determined that CAR T cells from STR and LTR have distinct metabolic states (Fig

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Notably, while mouse iTregs can be highly suppressive in vivo , human iTregs generated under similar conditions often fail to acquire full regulatory function, highlighting important species-specific differences ( 2.2 The functional antagonism between Th17 cells and Treg cells The functional antagonism between Th17 cells and Treg cells primarily manifests in their reciprocal interactions and regulatory mechanisms within the immune system

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