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The core monotherapy evidence comes from a phase 2 dose-finding trial with 706 adult participants with overweight or obesity over 26 weeks Lau et al., 202101751-7/abstract)

Modern research has identified specific inflammatory markers, including interleukin-1 beta and tumor necrosis factor-alpha, as key players in joint destruction

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however, 63 (10.5%) were intended for PCT, and 127 (21.1%) were declared as containing other PEDs (Figure 1.)