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Moreover, neither the total amount of supplied calories nor the concentration of blood glucose correlated with systemic levels of BHB (Extended Data Fig

This finding remained consistent across sub-analyses, including stratifications by sex

This highlights the potential treatment role of targeting the NLRP3 pathway in managing cardiac complications associated with dysbiosis and LPS-induced inflammation

However, the mechanism underlying its preventive effect is still unclear

The gap between a stable, potent peptide and a degraded vial comes down to cold chain management