However, a recognised limitation of these therapies is that up to 40% of the weight lost may come from lean mass, which includes skeletal muscle and connective tissue
This occurs because: Blood sugar monitoring becomes especially crucial during withdrawal to avoid hyperglycemia or the reappearance of diabetic symptoms like fatigue, blurred vision, or increased urination
Rather than pursuing unproven combinations of investigational and licensed agents, patients are encouraged to: Engage with NHS weight management services , which offer multidisciplinary support including dietary advice, behavioural therapy, and pharmacotherapy where appropriate including orlistat and, where eligible, GLP-1-based medicines Discuss licensed options with their GP if they meet eligibility criteria, including referral pathways for bariatric surgery in line with NICE obesity guidance Participate in clinical trials if interested in investigational agents such as retatrutide, through legitimate research pathways listed on the NIHR Clinical Research Network or ClinicalTrials.gov The safest and most effective treatments are those supported by robust clinical evidence, prescribed by qualified clinicians, and obtained through regulated supply chains
High blood sugar can affect energy, nerves, heart health and long term wellness
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Recent research has suggested a link between GLP-1 drug use and hair loss in adults with type 2 diabetes
