Nonetheless, insulin/IGF signaling has been demonstrated to attenuate inflammatory responses, e.g., in human myocardial infarction [21] and severe thermal trauma [22] as well as in many mouse models, such as colitis [23], vascular inflammation [24], IL-1-induced cartilage degradation [25], lipopolysaccharide-provoked brain injuries [26], and experimental multiple sclerosis and autoimmune diabetes [27, 28]
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This represents a clinically meaningful outcome that could substantially impact long-term health trajectories
Experimental models focused on gastrointestinal function
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Patients appreciate clear communication, realistic expectations, and a supportive environment in which semaglutide is used as one part of a broader, well-considered approach to long-term health