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Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells

The balance between ROS production and antioxidant responses, as well as the cellular context, determines the impact of ROS on necroptosis and the subsequent cellular outcome

[DOI] [PubMed] [Google Scholar] 173.Araki S., Izumiya Y., Hanatani S., Rokutanda T., Usuku H., Akasaki Y., Takeo T., Nakagata N., Walsh K., Ogawa H

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While this efficiency is generally beneficial, in environments of excess caloric intake it may contribute to fat accumulation

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