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OA is a degenerative disorder affecting the entire joint structure

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Peer review Peer review information Nature Communications thanks Hongli Mao, and the other, anonymous, reviewer for their contribution to the peer review of this work

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Additional triggers for eNOS phosphorylation include vascular endothelial growth factor (VEGF)-induced signal transduction, insulin-mediated activation of PKB/AKT, and bradykinin-induced activation of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII)

In mice heterozygous for the SPT subunit SPTLC2 (serine palmitoyltransferase, long-chain base subunit 2) there is a reduction in peripheral ceramide levels and improved insulin sensitivity when these animals are fed a high-fat diet