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(2008) Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone)

In rare cases, more serious risks can occur, such as pancreatitis, acute kidney injury, gallbladder issues

All model parameters were assumed log-normally distributed

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