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A GTT conducted on day 22 showed that both 10 and 30 mg/kg MEDI4166 treatment were able to significantly improve glucose tolerance (Supplementary Fig

Apolipoprotein C-III (Apoc3) is a component of triglyceride-rich lipoproteins that is known to stimulate monocytes in an NLRP3 inflammasome-dependent manner, resulting in pro-inflammatory activity (155)

Only 11.2 percent of such patients received a GLP-1 prescription, 6.3 percent received behavioural health services and 0.28 percent had bariatric surgery

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