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During the early preclinical stage of T1D, individuals often exhibit elevated levels of insulin autoantibodies [82]

This interference can cause falsely elevated or falsely low results that may lead to misdiagnosis

The results in our study that were most analogous to RCT results were among the top 10% of treated respondents for weight loss (i.e., average reduction of 15% at 12 months) and HbA1c (i.e., average reduction of 3% at 12 months), while the bottom 10% of treated respondents saw no change or slightly worsening outcomes over time

doi:10.1002/14651858.CD002025.pub5 Santo Jr T, Clark B, Hickman M, et al

Endpoints must be defined upfront according to the fertility pathway

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