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The combined effect of neurohormonal and RASS hyperactivity results in increased water and sodium retention, leading to volume overload (104), and cardiac and renal fibrosis, which is then aggravated with a functional decline (105)

Psychiatry Res (2010) 181:13640.10.1016/j.pscychresns.2009.08.006 137 HulvershornLAKarneHGunnADHartwickSLWangYHummerTAet alNeural activation during facial emotion processing in unmedicated bipolar depression, euthymia, and mania

Kim S.Y., Sharma A.J., Sappenfield W., Wilson H.G., Salihu HM Association of maternal body mass index, excessive weight gain, and gestational diabetes mellitus with large-for-gestational-age births

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Trelagliptin (syr-472, zafatek), novel once-weekly treatment for type 2 diabetes, inhibits dipeptidyl peptidase-4 (dpp-4) via a non-covalent mechanism

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